Metabolomics by in vivo NMR

About This Book

"In this book in vivo studies of metabolic fluxes in human muscle, heart and liver have utilized Metabolic Control Analysis (MCA) to relate metabolism to higher-level physiological functions. These novel approaches have located the genetic defect of Type II diabetes in recruitment of the muscle glucose transporter during glycogen synthesis, and have evaluated effects of diet and exercise upon this crucial step." "This book will appeal to the medical, biochemical and physiological communities, particularly those members who wish to understand the metabolic basis of human functions in modern quantitative terms, and the methods of in vivo NMR and Metabolic Control Analysis which have provided these insights."--Jacket.